Cell BiologybioRxiv
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
T. Tezil, M. Chamoli, C.-P. Ng…·E. Verdin
This study identifies p300 as a target of NDGA, showing it inhibits p300 acetyltransferase activity and activates autophagy, contributing to lifespan extension.