Jin‐Peng Sun

The paper identifies and characterizes small molecule allosteric modulators of the AT1R, revealing their conformational mechanisms and effects on G protein and β-arrestin pathways.

This study shows β-arrestin condensates regulate GPCR function through liquid-liquid phase separation, influencing internalization and signaling.

This paper reveals how mechanical force activates mGlu2 through a unique cis mechanism and induces distinct Gq coupling, providing structural insights and a chemical toolset for modulating mechanosensitive GPCRs.

This study identifies mGlu2 as a mechanosensitive GPCR in vestibular hair cells essential for balance, distinct from its role in hearing.

This study identifies LPHN2 as a force-sensing GPCR critical for auditory function, showing its role in mechanoelectrical transduction and hearing loss when deficient.

This study reveals the structural mechanism of cholesterol sensing by LYCHOS, showing how cholesterol binding modulates its interaction with GATOR1 to activate mTORC1.

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

The paper reports high-resolution structures of MC4R with agonists and reveals insights into ligand recognition and activation mechanisms.