BiochemistrybioRxivPreprint
Negative allosteric modulation of the μ-opioid receptor
Evan S. O’Brien, Vipin Ashok Rangari, Amal El Daibani…·Brian K. Kobilka
This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.
DOI 10.1101/2023.09.08.556921