Cell BiologybioRxivPreprint
Stag1 and Stag2 regulate cell fate decisions in hematopoiesis through non-redundant topological control
Aaron D. Viny, Robert L. Bowman, Yu Liu…·Ross L. Levine
The paper shows Stag2 loss in HSPCs impairs B-cell lineage commitment by reducing chromatin accessibility, while Stag1 cannot restore this function despite rescuing topological domains.