Aaron D. Viny

The paper identifies multi-hit STAG2 mutations in MDS patients, showing they are associated with worse outcomes and suggest convergent evolutionary targeting of the cohesin gene.

This study identifies Med4 as a regulator of metastatic dormancy in breast cancer, showing its role in maintaining chromatin structure and suppressing enhancer activation.

This study investigates how Stag2-dependent chromatin remodeling influences Gata1's function in erythropoiesis, revealing its role in lineage-specific gene regulation and dyserythropoiesis in MDS.

The paper identifies distal and interchromosomal chromatin interactions in T cells using a new algorithm and links them to gene regulation through epigenomic analysis.

This study shows that cohesin mutations alter chromatin accessibility, enhancing FLI1-Menin interaction and promoting leukemogenesis through therapeutic vulnerabilities.

ChromaFold predicts 3D chromatin contact maps from scATAC-seq data, outperforming bulk-based methods and enabling cell-type-specific interaction analysis.

This study shows that polyamines regulate cell fate by altering chromatin structure through interactions with histone-modifying enzymes.

This study identifies two sphingolipidomic subtypes in AML, with one subtype associated with poor clinical outcomes and high-risk features.

The paper shows Stag2 loss in HSPCs impairs B-cell lineage commitment by reducing chromatin accessibility, while Stag1 cannot restore this function despite rescuing topological domains.