Author

D. A. Case

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Approach:statistical model· 4 Assay:structural biology· 4 Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Rangadurai· 2 shared H. M. Al-Hashimi· 2 shared H. Shi· 2 shared N. Ando· 2 shared S. P. Meisburger· 2 shared A. Sam· 1 shared B. Liu· 1 shared B. Wang· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

A. Rangadurai

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6 papers

Recent·Most cited

Robust total X-ray scattering workflow to study correlated motion of proteins in crystals

S. P. Meisburger, D. A. Case, N. Ando

This paper introduces a workflow for analyzing protein motion in crystals using total scattering, with methods to subtract lattice disorder and validate results.

bioRxiv · Aug 22, 2022Biophysics

Molecular Dynamics Analysis of a Flexible Loop at the Binding Interface of the SARS-CoV-2 Spike Protein Receptor-Binding Domain

J. K. Williams, B. Wang, A. Sam, C. L. Hoop, D. A. Case, J. Baum

This paper uses molecular dynamics simulations to analyze the conformational flexibility of the SARS-CoV-2 RBD Loop 3 and identifies new unbound substates that could be therapeutic targets.

bioRxiv · Jan 8, 2021Biophysics

A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions

B. Liu, H. Shi, A. Rangadurai, F. Nussbaumer, C.-C. Chu, K. A. Erharter, D. A. Case, C. Kreutz, H. M. Al-Hashimi

The paper shows m6A modification slows nucleic acid hybridization by altering conformational dynamics through isomerization pathways.

bioRxiv · Dec 25, 2020Biochemistry

An RNA dynamic ensemble at atomic resolution

H. Shi, A. Rangadurai, H. Abou Assi, R. Roy, D. A. Case, D. Herschlag, J. D. Yesselman, H. M. Al-Hashimi

This study determines an atomic-resolution RNA ensemble for HIV-1 TAR using structure prediction and NMR refinement, revealing cooperative conformational changes.

bioRxiv · May 13, 2020 · PreprintBiophysics

The interplay between molten globules and heme disassociation defines human hemoglobin disassembly

P. P. Samuel, M. A. White, W. C. Ou, D. A. Case, G. N. Phillips, J. S. Olson

This paper develops a quantitative model of human hemoglobin disassembly, showing that heme dissociation and molten globule intermediates drive structural changes, leading to pathophysiological outcomes like Heinz bodies and hemolysis.

Biophysical Journal · Mar 1, 2020Peer-reviewedBiophysics

Diffuse X-ray Scattering from Correlated Motions in a Protein Crystal

S. P. Meisburger, D. A. Case, N. Ando

This study analyzes diffuse X-ray scattering from lysozyme crystals to understand collective atomic motions and their correlations, revealing the need for internal protein dynamics beyond lattice effects.

bioRxiv · Oct 17, 2019Biophysics