R. Roy

Podoplanin Positive Cell-derived Extracellular Vesicles Contribute to Cardiac Amyloidosis After Myocardial Infarction

This study identifies that Podoplanin-expressing mesenchymal stromal cells release exosomes that trigger SAA3 overproduction in macrophages, leading to cardiac amyloidosis after myocardial infarction.

Preclinical study of the human recombinant Erythropoietin (GBPD002) compared with Eprex

This study compares the safety and toxicity of GBPD002 and Eprex(R), two recombinant human erythropoietins, in rats, finding similar toxicological profiles and no significant differences.

Exploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs

This study uses high-throughput thermodynamic measurements to explore how sequence changes affect the binding properties of RNA tetraloop receptor motifs, revealing complex sequence-fitness landscapes.

H2O2 mediated MAPK-mTOR crosstalk determines the XIAP and FLIP degradation pathways and development of resistance to Imatinib

This study shows H2O2-mediated mTOR activation determines protein degradation pathway and Imatinib resistance in K562 cells.

IL6 mediated cFLIP downregulation increases the migratory and invasive potential of triple negative breast cancer cells

The paper shows that IL6-mediated cFLIP downregulation enhances metastasis in triple negative breast cancer by reducing autophagy.

Long-term cold selection leads to increased thermal plasticity of male body size and thermal canalization of fecundity in populations of Drosophila melanogaster

E-proteins set the threshold for optimal TCF1 expression during αβ T cell development.

This study shows E-proteins regulate TCF1 expression thresholds during T cell development, with EPE3 being critical for TCF1 levels and T cell differentiation.

Determining the shelf life of an erythropoietin alfa biosimilar GBPD002 through stability study

This study evaluates the stability of the erythropoietin alfa biosimilar GBPD002 under various environmental conditions and determines its shelf life as 24 months.

Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification

The paper uses multiomic single-cell profiling to show MPAL blasts have a stem-like transcriptional profile linked to poor prognosis and develops a gene score for clinical risk stratification.

Cholesterol catalyzes unfolding in membrane inserted motifs of the pore forming protein cytolysin A

This study shows cholesterol stabilizes an unfolded intermediate in the pore-forming toxin ClyA, lowering free energy barriers and enhancing pore formation kinetics.

Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape

This paper shows that mutations in SF3B1 and U2AF1 cause transcription elongation defects leading to chromatin changes and identifies targeting the Sin3/HDAC complex as a potential therapy.

Development and qualification of a high-yield recombinant human Erythropoietin biosimilar

This paper develops and characterizes a high-yield biosimilar of recombinant human erythropoietin (rhEPO) that meets regulatory requirements and offers a cost-effective alternative.

A Cost-effective Purification Process for Erythropoietin Biosimilar through Downstream Process Engineering

This study develops a scalable and reproducible downstream purification process for EPO biosimilar, meeting quality requirements and reducing production costs.

Post-secretory synthesis of a natural analog of iron-gall ink in the black nectar of Melianthus spp.

The paper identifies ellagic acid and iron as the black pigment in Melianthus nectar, showing post-secretory synthesis from gallic acid via peroxidase and iron(III).

RNA conformational propensities determine cellular activity

The paper alters and measures conformational propensities of HIV-1 TAR RNA to predict binding affinities and cellular activity.

Evolutionary dynamics of dengue virus in India

This study analyzes the evolutionary dynamics of dengue virus in India, identifying key genetic changes and immune-driven adaptations in circulating strains.

RGG motif-containing Scd6/LSM14A proteins regulate the translation of specific mRNAs in response to hydroxyurea-induced genotoxic stress

This study identifies Scd6/LSM14A proteins as regulators of mRNA translation during hydroxyurea-induced genotoxic stress, showing their role in modulating SRS2 and NHEJ factor mRNAs through arginine methylation.

Nucleic acid quantification with amplicon yield in recombinase polymerase amplification

This paper develops qeRPA, a semi-quantitative RPA method that estimates nucleic acid copy numbers using final amplicon yield, achieving sensitivity comparable to qPCR without real-time monitoring.

Conformational flexibility is a key determinant of the lytic activity of the pore forming protein, Cytolysin A

This study shows that conformational flexibility in the β-tongue and N-terminus regions of ClyA is essential for its lytic activity and membrane-mediated conformational transition.

pSNAP: Proteome-wide analysis of elongating nascent polypeptide chains

pSNAP profiles proteome-wide elongating nascent polypeptide chains, revealing translational repression and modification effects on ribosome-associated interactions.

Overriding defective FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in diabetic wound

The paper identifies impaired FPR1 chemotaxis signaling in diabetic neutrophils as a cause of infection vulnerability and shows that CCL3 can override this defect to improve infection control and healing.

Convergent evolution of a novel blood-red nectar pigment in vertebrate-pollinated flowers

This paper identifies a novel blood-red nectar pigment in two distantly related plants, showing convergent evolution through similar enzymatic pathways but different genes.

PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma

This study shows that PI3K inhibition improves radiation response in oesophageal adenocarcinoma patients resistant to neo-CRT by upregulating PTEN through miR-187.

RGG-motif protein Sbp1 is required for Processing body (P-body) disassembly

This study identifies Sbp1 as a P-body disassembly factor, showing its role in disassembling Edc3 granules and demonstrating the involvement of RGG-motif in granule disassembly.

BANCOVID, the first D614G variant mRNA-based vaccine candidate against SARS-CoV-2 elicits neutralizing antibody and balanced cellular immune response

This paper develops and characterizes an mRNA-LNP vaccine candidate targeting the D614G variant of SARS-CoV-2, showing neutralizing antibody and balanced cellular immune responses in preclinical trials.

Life cycle process dependencies of positive-sense RNA viruses suggest strategies for inhibiting productive cellular infection

The paper uses a dynamical model to analyze life cycle strategies of positive-sense RNA viruses and identifies early life cycle bottlenecks as targets for inhibiting infection.

Translation regulation of Japanese encephalitis virus revealed by ribosome profiling

This study uses ribosome profiling to identify translation regulation mechanisms in Japanese encephalitis virus, revealing frameshifting, tRNA dysregulation, and alternative initiation sites that affect viral protein synthesis and neuroinvasiveness.

A Peptide of the Amino-Terminus of GRK2 Induces Hypertrophy and Yet Elicits Cardioprotection after Pressure Overload

This study shows that a GRK2 amino-terminal peptide induces cardiac hypertrophy but protects against heart failure during pressure overload.

An RNA dynamic ensemble at atomic resolution

This study determines an atomic-resolution RNA ensemble for HIV-1 TAR using structure prediction and NMR refinement, revealing cooperative conformational changes.

Systems analyses of key metabolic modules of floral and extrafloral nectaries of cotton

The paper compares floral and extrafloral nectaries in cotton to show the conservation of the eccrine-based model of nectar synthesis across both types.