D. A. Drummond

An adaptive biomolecular condensation response is conserved across environmentally divergent species

The paper studies how stress-induced biomolecular condensation adapts to thermal environments across three yeast species, showing species-specific temperature tuning and conserved molecular features.

Adaptive preservation of orphan ribosomal proteins in chaperone-stirred condensates

During stress, molecular chaperones preserve 'orphan' ribosomal proteins in liquid-like condensates, maintaining them in a usable form and enabling efficient recovery from stress.

Sequential Activation and Local Unfolding Control Poly(A)-Binding Protein Condensation

This study uses HDX-MS to reveal that Pab1 condensation involves sequential activation of its RRMs through partial unfolding, driven by thermodynamic specificity.

Chaperones directly and efficiently disperse stress-triggered biomolecular condensates

This study shows that the yeast disaggregation system efficiently disperses heat-induced Pab1 condensates, revealing distinct molecular requirements compared to model substrates.

Transient intracellular acidification regulates the core transcriptional heat shock response

This study shows that intracellular acidification, not protein synthesis, is required for Hsf1 activation during heat shock in yeast.

An Escherichia coli nitrogen starvation response is important for mutualistic coexistence with Rhodopseudomonas palustris

The paper identifies an E. coli nitrogen starvation response as critical for stable mutualism with R. palustris through cross-feeding.