Author

T. Sosnick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. D. Jones· 1 shared A. L. Schilmiller· 1 shared D. A. Drummond· 1 shared D. Arac· 1 shared D. Chen· 1 shared D. Kahan· 1 shared E. Feldman· 1 shared E. Perozo· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

A. D. Jones

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4 papers

Recent·Most cited

Folding of Prestin's Anion-Binding Site and the Mechanism of Outer Hair Cell Electromotility

X. Lin, P. Haller, N. Bavi, N. Faruk, E. Perozo, T. Sosnick

This study investigates how Prestin's anion-binding site folding drives its voltage-sensitive conformational changes, revealing a unique mechanism for outer hair cell electromotility.

bioRxiv · Feb 27, 2023Biophysics

Sequential Activation and Local Unfolding Control Poly(A)-Binding Protein Condensation

R. Chen, D. Kahan, J. Shangguan, J. R. Sachleben, J. A. Riback, D. A. Drummond, T. Sosnick

This study uses HDX-MS to reveal that Pab1 condensation involves sequential activation of its RRMs through partial unfolding, driven by thermodynamic specificity.

bioRxiv · Sep 21, 2022 · PreprintBiophysics

Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein

K. Gaffney, R. Guo, M. D. Bridges, D. Chen, S. Muhammednazaar, M. Kim, Z. yang, A. L. Schilmiller, N. F. Faruk, X. Peng, A. D. Jones, L. Sun, W. L. Hubbell, T. Sosnick, H. Hong

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

bioRxiv · May 17, 2021Biophysics

Structural basis for adhesion G protein-coupled receptor Gpr126 function

K. Leon, R. Cunningham, J. Riback, E. Feldman, J. Li, T. Sosnick, M. Zhao, K. Monk, D. Arac

This study determines the structure of the zebrafish Gpr126 ECR, revealing a closed conformation stabilized by alternative splicing and a calcium-binding site, and shows how these features regulate receptor function.

bioRxiv · Oct 17, 2019Biochemistry