D. A. Joy

Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis

The paper tracks human pluripotent stem cells using deep neural networks to understand intrinsic behaviors during morphogenesis.

SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients

This study infects human iPSC-derived cardiac cells with SARS-CoV-2 and identifies novel cytopathic features in COVID-19 patient hearts, including myofibrillar fragmentation and DNA loss in cardiomyocytes.

Cardiac Cell-Derived Matrices Impart Age-Specific Functional Properties to Human Cardiomyocytes

The paper develops a method to create stable cardiac cell-derived matrices and shows that fetal and adult matrices impart distinct functional properties to cardiomyocytes, with collagen VI in fetal matrices enhancing oxidative respiration.

Bi-directional Impacts of Heterotypic Interactions in Engineered 3D Human Cardiac Microtissues Revealed by Single-Cell RNA-Sequencing and Functional Analysis

The paper uses single-cell RNA-sequencing and functional analysis to show how interactions between cardiac cells affect tissue properties over time.

Single cell determination of cardiac microtissue structure and function using light sheet microscopy

This study uses light sheet microscopy to analyze single-cell structure and function in 3D cardiac microtissues, revealing spatial and functional heterogeneity among cell types.

Optogenetic control of Wnt signaling for modeling early embryogenic patterning with human pluripotent stem cells

This study uses optogenetic control of Wnt signaling to induce mesendoderm differentiation and gastrulation-like morphogenesis in human pluripotent stem cells.

Spatiotemporal mosaic patterning of pluripotent stem cells using CRISPR interference

This study uses CRISPR interference to create spatiotemporal patterns in hiPSC colonies, revealing how gene knockdowns affect multicellular organization and symmetry breaking during development.