Author

T. C. McDevitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Organism:human· 7 Approach:experimental assay· 5 Research Focus:differential expression· 4 Assay:imaging· 4 Research Focus:cell-cell communication· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. A. Joy· 6 shared C. R. Simoneau· 3 shared M. Ott· 3 shared A. C. Silva· 2 shared A. R. G. Libby· 2 shared B. R. Conklin· 2 shared J. L. Baron· 2 shared N. J. Krogan· 2 shared

Activity by Year

2018-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersBioengineering

D. A. Joy

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Hepatitis C Virus Infects and Perturbs Liver Stem Cells

N. L. Meyers, T. Ashuach, D. E. Lyons, C. R. Simoneau, A. L. Erickson, T. T. Nguyen, M. Bouhaddou, M. M. Khalid, T. Y. Taha, V. Natarajan, J. L. Baron, N. Neff, F. Zanini, T. Mahmoudi, S. R. Quake, , M. Ott

This study identifies liver stem cells as targets of HCV infection, showing their transcriptional reprogramming and role in liver damage and cancer risk.

bioRxiv · Oct 26, 2021Microbiology

Liver Organoid and T Cell Coculture Models Cytotoxic T Cell Responses against Hepatitis C Virus

V. Natarajan, C. R. Simoneau, A. Erickson, N. L. Meyers, J. L. Baron, S. Cooper, M. Ott, T. C. McDevitt

This paper develops a microfluidic coculture system of liver organoids and T cells to study HCV-specific cytotoxic T cell responses in vitro.

bioRxiv · Aug 10, 2021 · PreprintImmunology

Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis

D. A. Joy, A. R. G. Libby, T. C. McDevitt

The paper tracks human pluripotent stem cells using deep neural networks to understand intrinsic behaviors during morphogenesis.

bioRxiv · Sep 21, 2020Bioengineering

SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients

J. A. Perez-Bermejo, S. S. Kang, S. J. Rockwood, C. R. Simoneau, D. A. Joy, G. N. Ramadoss, A. C. Silva, W. R. Flanigan, H. Li, K. Nakamura, J. D. Whitman, M. Ott, B. R. Conklin, T. C. McDevitt

This study infects human iPSC-derived cardiac cells with SARS-CoV-2 and identifies novel cytopathic features in COVID-19 patient hearts, including myofibrillar fragmentation and DNA loss in cardiomyocytes.

bioRxiv · Aug 25, 2020Cell Biology

Cardiac Cell-Derived Matrices Impart Age-Specific Functional Properties to Human Cardiomyocytes

M. A. Kauss, S. J. Rockwood, A. C. Silva, D. A. Joy, N. Mendoza-Camacho, M. N. Whittaker, E. Stevenson, N. J. Krogan, D. L. Swaney, T. C. McDevitt

The paper develops a method to create stable cardiac cell-derived matrices and shows that fetal and adult matrices impart distinct functional properties to cardiomyocytes, with collagen VI in fetal matrices enhancing oxidative respiration.

bioRxiv · Jul 31, 2020 · PreprintCell Biology

Bi-directional Impacts of Heterotypic Interactions in Engineered 3D Human Cardiac Microtissues Revealed by Single-Cell RNA-Sequencing and Functional Analysis

T. A. Hookway, O. B. Matthys, D. A. Joy, J. E. Sepulveda, R. Thomas, T. C. McDevitt

The paper uses single-cell RNA-sequencing and functional analysis to show how interactions between cardiac cells affect tissue properties over time.

bioRxiv · Jul 6, 2020 · PreprintBioengineering

Single cell determination of cardiac microtissue structure and function using light sheet microscopy

D. Turaga, O. B. Matthys, T. A. Hookway, D. A. Joy, M. Calvert, T. C. McDevitt

This study uses light sheet microscopy to analyze single-cell structure and function in 3D cardiac microtissues, revealing spatial and functional heterogeneity among cell types.

bioRxiv · Jan 22, 2020Bioengineering

Spatiotemporal mosaic patterning of pluripotent stem cells using CRISPR interference

A. R. G. Libby, D. A. Joy, P.-L. So, M. A. Mandegar, J. M. Muncie, V. M. Weaver, B. R. Conklin, T. C. McDevitt

This study uses CRISPR interference to create spatiotemporal patterns in hiPSC colonies, revealing how gene knockdowns affect multicellular organization and symmetry breaking during development.

bioRxiv · Jan 24, 2018Bioengineering