R. Thomas

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and B-lactam antibiotics.

The paper shows that purine and pyrimidine synthesis pathways influence the strength of the inoculum effect differently for beta-lactam and aminoglycoside antibiotics.

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype

The paper identifies an X4-tropic HIV-1 transmitted/founder virus in a person with wild-type CCR5, showing faster CD4 depletion and resistance to certain bNAbs.

New insights into the systematics of the Afrotropical Amblyomma marmoreum complex (Acari, Ixodidae) and a novel Rickettsia africae strain using morphological and metagenomic approaches

This study uses morphology and metagenomics to characterize A. sparsum ticks and identify a novel Rickettsia africae strain, clarifying its position within the A. marmoreum complex.

TOM20 Gates PINK1 Activity And Mediates Its Tethering Of The TOM And TIM23 Translocases Upon Mitochondrial Stress

This study shows PINK1 forms a supercomplex with TOM and TIM23 during mitochondrial stress and is required for tethering TOM to TIM23, which is essential for mitophagy.

Post-acute immunological and behavioral sequelae in mice after Omicron infection

This study investigates post-acute immunological and behavioral effects in mice after Omicron infection, showing vaccination reduces pulmonary immune perturbations and behavioral deficits.

Modulation of SLFN11 induces changes in DNA Damage response

This study shows that increasing SLFN11 expression through CRISPR-dCas9 systems enhances DNA damage response sensitivity in breast cancer cells.

Incidences of Helicobacter infection in pigs and tracing occupational hazard in pig farmers

The paper assesses Helicobacter prevalence in pigs and pig farmers, finding 19.63% of pig stomach samples and 2.08% of farmer stool samples positive for H. suis, with 3.12% positive for H. pylori.

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

Monkeypox DNA correlates with virus infectivity in clinical samples

The paper correlates Monkeypox DNA content with virus infectivity in clinical samples and defines a PCR threshold for non-infectious virus.

Deficiencies of Runx3 and tissue-resident CD4+ intestinal epithelial lymphocytes link intestinal dysbiosis and inflammation in mouse and human spondyloarthropathy

RMeDPower2 for Biology: guiding the design, experimental structure and analyses of experiments generating repeated measures datasets

RMeDPower2 helps researchers design and analyze repeated measures experiments by providing statistical tools based on GLMMs to improve reproducibility and power.

Deep Immunophenotyping Reveals Endometriosis is Marked by Dysregulation of the Mononuclear Phagocytic System in Endometrium and Peripheral Blood

This study uses mass cytometry to analyze immune cell phenotypes in endometriosis patients, finding dysregulated mononuclear phagocytic system in endometrium and blood.

Accumulation of Treg cells is detrimental in late-onset (aged) mouse model of multiple sclerosis

This study shows that accumulated Treg cells in aged mice worsen experimental autoimmune encephalomyelitis (EAE) by disrupting Treg/Teff balance and impairing CNS immune cell trafficking.

Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells from HIV+ Controllers and Non-Controllers

This study compares T and NK cell phenotypes in blood and lymph nodes of HIV+ controllers and ART-treated individuals, finding distinct cellular features in lymphoid tissues.

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy

This study shows SARS-CoV-2 Spike protein causes abnormal blood clots and thromboinflammation, which are neutralized by a fibrin-targeting antibody.

Plant lipid metabolism in susceptible and tolerant soybean (Glycine max) cultivars in response to Phytophthora sojae colonization and infection

This study investigates lipid metabolism changes in soybean cultivars resistant and susceptible to Phytophthora sojae, identifying lipid biomarkers that may aid in developing plant protection strategies.

Recurrent Vulvovaginal Candidiasis; a dynamic interkingdom biofilm disease of Candida and Lactobacillus

This study investigates RVVC by analyzing the vaginal microbiome and interactions between Candida and Lactobacillus, finding reduced L. crispatus and increased L. iners, and showing Lactobacillus inhibition of Candida biofilm formation.

Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ER+ breast cancer cells.

The paper investigates Hes1 oscillations in ER+ breast cancer cells, showing that phase shifts in these oscillations relative to mitosis correlate with cell-cycle length heterogeneity and cancer stem cell properties.

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

This study identifies novel fusion genes in human angiosarcomas and canine hemangiosarcomas, showing convergent transcriptional programs driven by these fusions and mutations in TP53 and PI3K/AKT/mTOR pathway genes.

Dendritic cells focus CTL responses toward highly conserved and topologically important HIV epitopes

This study uses dendritic cells to focus CD8+ T cell responses on conserved and topologically important HIV epitopes to prevent immune escape.

Bi-directional Impacts of Heterotypic Interactions in Engineered 3D Human Cardiac Microtissues Revealed by Single-Cell RNA-Sequencing and Functional Analysis

The paper uses single-cell RNA-sequencing and functional analysis to show how interactions between cardiac cells affect tissue properties over time.

The Atlas of the In Vivo HIV CD4 T Cell Reservoir

The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.

Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence

This paper identifies methionine synthase as a promising antifungal target by showing its essentiality in Aspergillus fumigatus and validates its druggability using a genetic model of established infections.

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α

This study shows that nSMase2 regulates TNF-α-induced inflammatory responses in monocytes/macrophages by affecting CD11c expression and inflammatory mediator secretion.

Thymic rejuvenation via induced thymic epithelial cells (iTECs) from FOXN1-overexpressing fibroblasts to counteract inflammaging

This paper demonstrates that induced thymic epithelial cells (iTECs) from FOXN1-overexpressing fibroblasts can rejuvenate aged thymus and reduce inflammaging in mice.

Mutational, transcriptional and viral shedding dynamics of the marine turtle fibropapillomatosis tumor epizootic

This study investigates the mutational, transcriptional, and viral shedding dynamics of fibropapillomatosis in marine turtles, revealing molecular differences between tumor types and identifying potential therapeutic targets.

Can school children support ecological research? Lessons from the ‘Oak bodyguard’ citizen science project

The paper evaluates schoolchildren's ability to collect ecological data through a citizen science project and finds their data require calibration but are comparable to untrained professionals.

Whole chromosome loss in tetraploid cells confers tumorigenic potential in a mouse allograft model

This study shows that whole chromosome loss in tetraploid cells leads to tumorigenic potential in a mouse model by increasing chromosomal instability and DNA damage.