Cell BiologybioRxiv
RASopathy Mutations Provide Functional Insight into the BRAF Cysteine-rich Domain and Demonstrate the Importance of Autoinhibition in BRAF Regulation
R. Spencer-Smith, E. M. Terrell, C. Insinna…·D. K. Morrison
This study examines RASopathy mutations in the BRAF cysteine-rich domain, showing they increase BRAF activity by relieving autoinhibition and enhancing PS binding, with autoinhibition being the main factor affecting mutation severity.
DOI 10.1016/j.molcel.2022.10.016