Author

D. K. Morrison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Organism:zebrafish· 1

Frequent Co-Authors

E. M. Terrell· 2 shared A. G. Stephen· 1 shared A. Liu· 1 shared C. Agamasu· 1 shared C. B. Marshall· 1 shared C. Insinna· 1 shared C. Mattos· 1 shared C. W. Johnson· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

E. M. Terrell

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

RASopathy Mutations Provide Functional Insight into the BRAF Cysteine-rich Domain and Demonstrate the Importance of Autoinhibition in BRAF Regulation

R. Spencer-Smith, E. M. Terrell, C. Insinna, C. Agamasu, M. E. Wagner, D. A. Ritt, J. Stauffer, A. G. Stephen, D. K. Morrison

This study examines RASopathy mutations in the BRAF cysteine-rich domain, showing they increase BRAF activity by relieving autoinhibition and enhancing PS binding, with autoinhibition being the main factor affecting mutation severity.

bioRxiv · Oct 1, 2021Cell Biology

Structural Insights into the BRAF Monomer-to-dimer Transition Mediated by RAS Binding

J. A. Martinez Fiesco, D. E. Durrant, D. K. Morrison, P. Zhang

The paper presents cryo-EM structures of BRAF complexes to elucidate how RAS binding initiates conformational changes leading to dimer formation.

bioRxiv · Sep 30, 2021Biochemistry

Regulation of GTPase function by autophosphorylation

C. W. Johnson, H.-S. Seo, E. M. Terrell, F. KleinJan, T. Gebregiworgis, G. M. C. Gasmi-Seabrook, E. A. Geffken, J. Lakhani, K. Song, O. Popow, J. A. Paulo, A. Liu, C. Mattos, C. B. Marshall, M. Ikura, , K. M. Haigis

This study shows autophosphorylation of small GTPases like H-RAS and K-RAS alters their nucleotide exchange and effector interactions, changing their functional behavior.

bioRxiv · Jun 23, 2021Biochemistry