D. Arbon

Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.

This paper demonstrates that MitoTam, a mitochondria-targeted tamoxifen analog, effectively kills various pathogens including fungi, Plasmodium falciparum, and trypanosomatid parasites in vitro and in vivo.

Adaptive iron utilization compensates for the lack of an inducible uptake system in Naegleria fowleri and represents a potential target for therapeutic intervention

This study shows that Naegleria fowleri uses mitochondrial iron to maintain respiration under iron starvation and suggests targeting this pathway for therapy.