L. Werner

Selective killing of cancer cells via simultaneous destabilization of mitochondrial iron metabolism and induction of ferroptosis elicited by mitochondrially targeted iron chelator deferasirox

This study introduces mitoDFX, a mitochondrially targeted iron chelator that simultaneously depletes iron and induces ferroptosis, showing high selectivity and efficacy against cancer cells.

Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.

This paper demonstrates that MitoTam, a mitochondria-targeted tamoxifen analog, effectively kills various pathogens including fungi, Plasmodium falciparum, and trypanosomatid parasites in vitro and in vivo.

Single cell atlas of the neonatal small intestine with necrotizing enterocolitis

This study uses single-cell and bulk RNA sequencing to identify cellular changes and interactions in necrotizing enterocolitis, highlighting inflammatory macrophages, T cells, and epithelial-mesenchymal-immune interactions.