M. Machado

Plasmodium falciparum CRK4 links early mitotic events to the onset of S-phase during schizogony

The paper identifies PfCRK4 as a kinase that links early mitotic events to the onset of S-phase in Plasmodium falciparum schizogony by orchestrating DNA replication and microtubule rearrangement.

An Sfi1-like centrin-interacting centriolar plaque protein affects nuclear microtubule homeostasis.

The paper identifies a novel centrin-interacting centriolar plaque protein in Plasmodium falciparum and shows its role in regulating nuclear microtubule homeostasis.

Spontaneous genomic variation as a survival strategy of nosocomial S. haemolyticus

This study examines genetic and phenotypic variation in S. haemolyticus during in vitro passage, revealing subpopulations that may enhance survival under stress.

Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.

This paper demonstrates that MitoTam, a mitochondria-targeted tamoxifen analog, effectively kills various pathogens including fungi, Plasmodium falciparum, and trypanosomatid parasites in vitro and in vivo.

Asynchronous nuclear cycles in multinucleated Plasmodium falciparum enable rapid proliferation

The paper shows that Plasmodium falciparum nuclei replicate DNA asynchronously, leading to heterogeneous progeny numbers and slower replication during overlapping events.

An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum

This study identifies an extended intranuclear compartment in Plasmodium falciparum that nucleates microtubules during schizogony, revealing a novel centrosome structure.

A Library Of Induced Pluripotent Stem Cells From Clinically Well-Characterized, Diverse Healthy Human Individuals

The paper generates and characterizes a diverse library of hiPSCs from healthy humans for use in disease modeling and drug response studies.

Sponging of glutamate at the outer plasma membrane surface reveals roles for glutamate in development

The paper shows that surface-displayed glutamate sensors affect plant development by sequestering glutamate at the plasma membrane, suggesting its role in signaling during growth and differentiation.

The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture

This paper examines the genetic structure and adaptation of Andean highlanders and Amazonian dwellers, showing how geography and culture influence genetic differentiation and natural selection.