Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
R. Barreira da Silva, R. Leitao, X. Pechuan, S. Werneke, J. Oeh, V. Javinal, Y. Wang, W. Phung, C. Everett, J. Nonomiya, D. Arnott, C. Lu, Y.-C. Hsiao, J. T. Koerber, I. Hotzel, , M. Albert
This study shows that QPCTL inhibition reduces monocyte migration and alters myeloid cell infiltration, enhancing anti-tumor immunity when combined with anti-PD-L1 therapy.
bioRxiv · Jan 25, 2022Immunology