Author

I. Mellman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

Z. Modrusan· 3 shared M. Albert· 2 shared R. Barreira da Silva· 2 shared Y. Wang· 2 shared A. A. Cass· 1 shared A. Ashkenazi· 1 shared A. Baz Morelli· 1 shared A. Charap· 1 shared

Activity by Year

2016-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

Z. Modrusan

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer

B. Salome, J. P. Sfakianos, J. Daza, A. Charap, C. Hammer, R. Banchereau, A. M. Farkas, D. Geanon, G. Kelly, R. M. de Real, B. Lee, K. G. Beaumont, S. Shroff, Y. S. A. Wang, Y.-C. Wang, , Mariath

This study identifies NKG2A and HLA-E as an alternative immune checkpoint axis in bladder cancer, showing NKG2A+ CD8 T cells can bypass HLA-ABC loss through TCR-independent cytotoxicity.

bioRxiv · Mar 4, 2022 · PreprintImmunology

Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

R. Barreira da Silva, R. Leitao, X. Pechuan, S. Werneke, J. Oeh, V. Javinal, Y. Wang, W. Phung, C. Everett, J. Nonomiya, D. Arnott, C. Lu, Y.-C. Hsiao, J. T. Koerber, I. Hotzel, , M. Albert

This study shows that QPCTL inhibition reduces monocyte migration and alters myeloid cell infiltration, enhancing anti-tumor immunity when combined with anti-PD-L1 therapy.

bioRxiv · Jan 25, 2022Immunology

An open-access volume electron microscopy atlas of whole cells and tissues

C. S. Xu, S. Pang, G. Shtengel, A. Müller, A. T. Ritter, H. K. Hoffman, S.-y. Takemura, Z. Lu, H. A. Pasolli, N. Iyer, J. Chung, D. Bennett, A. V. Weigel, M. Freeman, S. B. van Engelenburg, , H. Hess

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

Nature · Oct 6, 2021Peer-reviewedCell Biology

Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells

O. Guttman, A. Le Thomas, S. A. Marsters, D. A. Lawrence, L. Gutgesell, J. M. Harnoss, S. M. Haag, A. Murthy, G. Strasser, Z. Modrusan, T. Wu, I. Mellman, A. Ashkenazi

The paper shows antigen-derived peptides activate IRE1α in dendritic cells, reducing MHC-I expression and cross-presentation, and demonstrates that IRE1 inhibition enhances anti-tumor immunity.

bioRxiv · Sep 10, 2021Cell Biology

Surveillance of in situ tumor arrays reveals early environmental control of cancer immunity

G. Ortiz-Munoz, M. Brown, C. B. Carbone, J. Pechuan Jorge, A. Ritter, D. Orlova, S. R. Mantri, A. Yang, J. Doerr, S. Mariathasan, Y. Wang, S. Turley, C. Gomez-Roca, C. Eduardo de Andrea, D. Spigel, , C. Moussion

This study introduces STAMP, a method to monitor tumor-immune dynamics in vivo, showing immune phenotypes evolve over time and correlate with therapeutic response.

bioRxiv · May 27, 2021 · PreprintCancer Biology

Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation

S. Nalle, R. Barreira da Silva, H. Zhang, M. Decker, C. Chalouni, M. Xu, G. Posthuma, A. de Maziere, J. Klumperman, A. Baz Morelli, S. Fleire, A. Verkman, S. Trombetta, M. Albert, I. Mellman

This study identifies aquaporin-3 as a regulator of endosome-to-cytosol transfer by facilitating hydrogen peroxide entry, which induces lipid peroxidation and antigen release.

bioRxiv · Aug 19, 2020Immunology

Transposable Element Expression In Tumors Is Associated With Immune Infiltration And Increased Antigenicity

Y. Kong, C. Rose, A. A. Cass, M. Darwish, S. Lianoglou, P. M. Haverty, A.-J. Tong, C. Blanchette, I. Mellman, R. Bourgon, G. John, S. Jhunjhunwala, M. L. Albert, H. Chen-Harris

The paper shows that transposable element expression in tumors correlates with immune infiltration and increased antigenicity, suggesting potential synergy with immunotherapy.

bioRxiv · Aug 9, 2018Cancer Biology

T cell co-stimulatory receptor CD28 is a primary target for PD-1-mediated inhibition

E. Hui, J. Cheung, J. Zhu, X. Su, M. J. Taylor, H. A. Wallweber, D. K. Sasmal, J. Huang, J. M. Kim, I. Mellman, R. D. Vale

This study shows PD-1 inhibits T cell activation by preferentially dephosphorylating CD28 over TCR, revealing CD28 as a primary target for PD-1-mediated suppression.

bioRxiv · Nov 9, 2016Biochemistry