I. Hotzel

Transfer and Capture of Envelope Protein Receptor-Binding Domains in the Retroviruses

The paper identifies multiple RBD transfer events in retroviruses through phylogenetic analysis and structural modeling, revealing an endogenous alpharetroviral-like Env with an IgV domain fold acquired from mammalian genes.

Structural Evolution of Trimeric Gamma-Type Retroviral Envelope Proteins

This study models trimeric gamma-type retroviral Env structures using AlphaFold2 to explore their structural evolution and functional differences.

Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

This study shows that QPCTL inhibition reduces monocyte migration and alters myeloid cell infiltration, enhancing anti-tumor immunity when combined with anti-PD-L1 therapy.

Deep time structural evolution of retroviral and filoviral surface envelope proteins

The paper uses structural modeling to identify a conserved β-sandwich domain in retroviral and filoviral envelope proteins, showing its evolutionary conservation and role in structural diversity.

Domain Organization of Lentiviral and Betaretroviral Surface Envelope Glycoproteins Modeled with AlphaFold

The paper uses AlphaFold to model surface envelope glycoproteins of lentiviruses and betaretroviruses, identifying structural domains and potential receptor-binding sites.

Heavy Chain CDR 3 and Junctional Length Biases in Human Antibody Repertoires Associated with Heavy and Light Chain Germline Utilization

This study identifies biases in CDR H3 length and junctional length in human antibody repertoires linked to germline segment utilization during B cell maturation.

Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies

The paper uses scBCR-seq to analyze B-cell repertoires and identifies antigen-reactive antibodies with high accuracy.