D. B. Kell

Automated microscopic measurement of fibrinaloid microclots and their degradation by nattokinase, the main natto protease

The paper describes an automated method to measure fibrinaloid microclots and shows nattokinase degrades them in vitro.

VAE-Sim: a novel molecular similarity measure based on a variational autoencoder

VAE-Sim introduces a variational autoencoder to compute molecular similarity, offering a novel metric that outperforms traditional fingerprint-based methods.

A palette of fluorophores that are differentially accumulated by wild-type and mutant strains of Escherichia coli: surrogate ligands for bacterial membrane transporters

The paper identifies 39 fluorophores differentially accumulated by wild-type and mutant E. coli strains, serving as surrogates for bacterial membrane transporter assays.

An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines

The paper develops an untargeted metabolomics method to measure differences in metabolite uptake and excretion by mammalian cell lines using human serum.

The Atypical Fibrin Fibre Network in Rheumatoid Arthritis and its Relation to Autoimmunity, Inflammation and Thrombosis

This study compares coagulation, inflammation, and fibrin structure in RA patients and controls, finding denser fibrin networks and citrullination in RA.

Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters

The paper shows that mutations increasing efflux pump activity are more effective than inhibiting uptake transporters in reducing antibiotic internal concentrations, suggesting efflux inhibition as a better strategy for combating resistance.

Engineering the yeast Saccharomyces cerevisiae for the production of L-(+)-ergothioneine

This paper engineers Saccharomyces cerevisiae to produce L-(+)-ergothioneine through fermentation, achieving a titer of 598 mg/L.

Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of microbial (re)growth

This study uses flow cytometry to rapidly assess antimicrobial susceptibility during the lag phase of E. coli growth, showing susceptibility can be detected within 20 minutes.

Energetic Evolution of Cellular Transportomes

The paper analyzes the evolution of transportomes across bacteria, archaea, and eukarya, finding increased energetic efficiency in eukaryotes and potential mitochondrial origins in specific bacterial species.

Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father

This paper explores the role of paternal semen microbes in pre-eclampsia by linking immunological tolerance, infection, and microbial inoculation during pregnancy.

Both Lipopolysaccharide And Lipoteichoic Acids Potently Induce Anomalous Fibrin Amyloid Formation: Assessment With Novel Amytracker™ Stains

The paper shows that LPS and LTAs induce amyloid-like fibrin formation, detected by Amytracker™ stains and viscometry, suggesting a role in inflammatory coagulopathies.