S. Samanta

Intra-DNA k-mer Conservation Patterns Encode Evolutionary Selection of Variants

The paper introduces kGain, a metric quantifying k-mer frequency shifts due to mutations, and shows it predicts adaptive potential across species and experimental systems.

Syntaxin-2 coordinates endolysosomal trafficking to balance phagocytic uptake and phagolysosomal clearance in macrophages

This study identifies syntaxin-2 as a regulator of phagocytic uptake and phagolysosomal clearance in macrophages by coordinating receptor density, cup expansion, and maturation.

Functional diversity in the Hsp60 of Sulfolobus acidocaldarius: mosaic of Group I and Group II chaperonin

This study investigates the functional mechanisms of Hsp60 in Sulfolobus acidocaldarius, revealing its role in protein folding and membrane protection under stress.

Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

This study shows Leishmania major manipulates host copper homeostasis to evade immune responses, while macrophages use copper to kill parasites.

A novel role of macrophage PIST protein in regulating Leishmania major infection

This study shows that macrophage PIST protein regulates Leishmania major infection by interacting with Beclin 1 and affecting parasite replication.

Heparin-derived theranostic nanoprobes overcome the blood-brain barrier and target glioma in murine model

This study develops heparin-derived nanoprobes that cross the blood-brain barrier and target glioma in mice, showing effective imaging and therapeutic potential.

VAE-Sim: a novel molecular similarity measure based on a variational autoencoder

VAE-Sim introduces a variational autoencoder to compute molecular similarity, offering a novel metric that outperforms traditional fingerprint-based methods.