Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
E. Akabuougu, L. Zhang, R. Krasovec, I. Roberts, T. A. Waigh
The paper demonstrates that E. coli biofilms exhibit negative capacitance at low frequencies in electrical impedance spectroscopy, similar to neuronal behavior, and links this to voltage-gated potassium channels.
bioRxiv · Nov 24, 2023Biophysics
V. Carneiro da Cunha Martorelli, E. Akabuogu, R. Krasovec, I. Roberts, T. A. Waigh
The paper models electrical signaling in E. coli biofilms using a fire-diffuse-fire model, showing that wavefronts exhibit super-diffusive scaling and are influenced by geometry and ion diffusivity.
bioRxiv · Nov 17, 2023 · PreprintBiophysics
J. Moran, L. Feltham, J. Bagnall, M. C. Goldrick, E. A. Lord, C. Nettleton, D. G. Spiller, I. Roberts, P. Paszek
This study uses live-cell microscopy to show that L. monocytogenes infection of macrophages leads to heterogeneous outcomes, with non-cooperative bacterial behavior and population-level PrfA regulation affecting replication success.
bioRxiv · Jun 4, 2022 · PreprintMicrobiology
A. R. Cross, C. de Andrea, M. Villalba-Esparza, M. Landecho Acha, L. Cerundolo, P. Weeratunga, R. Etherington, L. Denney, G. Ogg, L.-P. Ho, I. Roberts, J. Hester, P. Klenerman, I. Melero, S. Sansom, F. Issa
The paper uses spatial transcriptomics to identify immune circuits in severe COVID-19 lung tissue, finding IFNγ response signatures linked to alveolar damage.
bioRxiv · Jun 21, 2021Immunology
S. Rice, T. Jackson, N. T. Crump, N. Fordham, N. Elliott, S. O Byrne, S. Inglott, D. Ladon, G. Wright, J. Bartram, P. Ancliff, A. J. Mead, C. Halsey, I. Roberts, T. A. Milne, A. Roy
bioRxiv · Nov 15, 2020 · PreprintCancer Biology
K. Ponnusamy, M. M. Tzioni, M. Begum, M. E. Robinson, V. S. Caputo, A. Katsarou, N. Trasanidis, X. Xiao, I. V. Kostopoulos, D. Iskander, I. Roberts, P. Trivedi, H. W. Auner, K. Naresh, A. Chaidos, A. Karadimitris
The paper shows that the ZBP1-IRF3 axis promotes myeloma cell proliferation by activating cell cycle genes instead of type I IFN responses.
bioRxiv · Jun 17, 2020Cancer Biology
M. Wright Muelas, I. Roberts, F. Mughal, S. O'Hagan, P. J. Day, D. B. Kell
The paper develops an untargeted metabolomics method to measure differences in metabolite uptake and excretion by mammalian cell lines using human serum.
bioRxiv · Jun 2, 2020Biochemistry
G. Juban, N. Sakakini, H. Chagraoui, Q. Cheng, K. Soady, B. Stoilova, C. Garnett, D. Waithe, J. Doondeea, B. Usukhbayar, E. Karkoulia, M. Alexiou, J. Strouboulis, E. Morrissey, I. Roberts, , P. Vyas
This study identifies stage-specific differentiation delays caused by GATA1s in megakaryocytes, leading to increased immature cells and altered gene expression.
bioRxiv · Oct 3, 2019Cell Biology
B. Psaila, G. Wang, A. Rodriguez Meira, E. F. Heuston, R. Li, J. O'Sullivan, N. Sousos, S. Anderson, Y. Senis, O. Weinberg, M. L. Callicchio, NIH Intramural Sequencing Core, D. Iskander, D. Royston, D. Milojkovic, , A. J. Mead
The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.
bioRxiv · May 20, 2019Cancer Biology
E. Louka, B. Povinelli, A. Rodriguez Meira, G. Buck, N. Ashley, A. Hamblin, C. A. G. Booth, N. Sousos, A. Roy, N. Elliott, D. Iskander, J. De la Fuente, N. Fordham, S. O'Byrne, S. Inglott, , A. Mead
This study identifies heterogeneous leukemia stem cells in JMML using single-cell RNA-sequencing and clonogenic assays, revealing their molecular features and potential therapeutic targets.
bioRxiv · May 7, 2019Cancer Biology