D. B. Oelz

The paper develops a mathematical model to study the dynamics of axonal transport of large cargo vesicles interacting with the membrane-associated periodic cytoskeletal structure.

The paper shows that microtubules form a mechanostat to coordinate contractility and nuclear positioning during confined cell migration.

The paper models actomyosin contraction at the filament scale, showing that F-actin bending reduces expansive stress and enables net contraction through geometric asymmetry.

The paper develops a Markov state model to describe neurosecretory vesicle transport and binding kinetics, showing spatial redistribution upon stimulation accelerates directed transport to the plasma membrane.

This study uses mathematical modeling to show that protein friction and actin filament bending are necessary for contraction of disordered actomyosin networks, with filament turnover required to sustain contraction.