PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
T. A. M. Chessa, P. Jung, S. Suire, A. Anwar, K. E. Anderson, D. Barneda, A. Kielkowska, B. A. Sadiq, D. Oxley, S. Felisbino, D. Spensberger, A. Segonds-Pichon, M. Wilson, S. Walker, H. Okkenhaug, , L. R. Stephens
The paper identifies PLEKHS1 as a driver of PI3K activity in PTEN-null prostate tissue, showing it bypasses feedback mechanisms to promote tumour progression.
bioRxiv · May 18, 2023Cell Biology