Q. Zheng

The paper uses spatial transcriptomics and single-cell RNA sequencing to identify cellular organization patterns and immune microenvironment changes in early lung adenocarcinoma progression.

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

The paper determines the crystal structure of phytoplasma effector SAP05 bound to plant Rpn10, revealing a ubiquitin-independent degradation mechanism and conserved interaction patterns across species.

This paper develops covalent inhibitors that target the K-Ras(G12D) mutation by crosslinking aspartate-12 in both GDP- and GTP-states, effectively suppressing cancer cell proliferation and tumor growth.

This study determines the structural mechanism of HECT-type E3 ligase Ufd4 in catalyzing K29/K48-branched polyubiquitination by capturing structural snapshots of Ub transfer cascades.

This paper introduces a chromogenic in situ hybridization method to measure telomere lengths in prostate tissues, aiding in the identification of precancerous lesions.

The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study shows that CVC1302 in oil formulation enhances Th1 immune responses by targeting antigen and inflammatory monocytes to lymph node inter-follicular regions and promoting IL-12 production by cDC2.

This study analyzes the genome and multi-omics data of a C4 plant to uncover evolutionary mechanisms behind C4 photosynthesis development.

The paper identifies novel microbiota-mediated mechanisms of colonization resistance to MRSA in pig skin using a swine model and isolates.

The paper uses 13C-tracing to study plant uptake of exometabolites across multiple species, finding that uptake accounts for 23% of the carbon budget in Brachypodium distachyon and that some metabolites promote root growth.

This study reports ploidy variation and spontaneous haploid-diploid switching in 500 clinical Candida glabrata isolates, revealing differences in morphology, antifungal susceptibility, virulence, and gene expression.

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

The paper analyzes mutational biases across 537 fungal strains from Ascomycota, finding variation in A|T and G|C substitution patterns and showing that genome composition is influenced by both mutational bias and selection.

The paper investigates the accessibility of the switch-II pocket in various KRAS mutants using NMR and a cellular engagement assay, showing it is accessible with non-covalent ligands regardless of GDP state.

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.

This study shows that knocking out OsSWEET15 in rice reduces fertility by impairing embryo formation and seed-setting, with similar effects observed in OsSWEET11 mutants.

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

This study shows PPAR-delta drives metabolic reprogramming in pancreatic cancer, promoting metastasis, and its inhibition reduces invasiveness.

The paper investigates ghrelin proteolysis by insulin-degrading enzyme, identifying cleavage sites and developing a fluorogenic substrate for future studies.

This study identifies NbGRP7 as a novel RNA-binding protein that enhances immunity by interacting with Gpa2 and Rx1, regulating their function through an intact RNA recognition motif.

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

The paper profiles single-cell transcriptomes of decidual macrophages in normal and recurrent spontaneous abortion patients, identifying distinct polarization states and potential therapeutic targets.

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

This study presents cryo-EM structures of human p97 complex with and without inhibitor NMS-873, revealing conformational changes and allosteric inhibition mechanisms.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study identifies a potent inhibitor of the ENL/AF9 YEATS domain and demonstrates its selective suppression of ENL-dependent leukemia genes.

This study identifies sAB-K29, a tool to detect K29-linked polyubiquitin, and shows its role in proteotoxic stress response and cell cycle regulation.