M. Wilson

Age- and estrous-dependent effects of psilocybin in rats

This study examines age- and estrous-dependent effects of psilocybin in rats, finding no long-term behavioral changes after adolescent exposure but differences in head twitch responses.

Soil organic carbon stocks and stabilization mechanisms in tidal marshes along estuarine gradients

This study examines SOC stocks and stabilization mechanisms in tidal marshes along estuarine gradients, finding that salinity and flooding reduce SOC storage and alter organic matter fractions.

Partitioning biota along the Elbe River estuary: where are the community transitions?

The paper examines community transitions in the Elbe River estuary, finding two distinct communities for plants and soil bacteria but not for aquatic microbes.

Local cryptic diversity in salinity adaptation mechanisms in a wild outcrossing Brassica

This study identifies contrasting salinity adaptation mechanisms in neighboring Brassica fruticulosa populations using genomic and transcriptomic analyses.

Chromosome-scale genome assembly of bread wheat's wild relative Triticum timopheevii

This study presents a chromosome-scale genome assembly of Triticum timopheevii using PacBio HiFi and Hi-C data, revealing genomic features and relationships between wheat genomes.

Adherent reformed islets: a long-term primary cell-based platform for exploring mouse and human islet biology.

This study develops a long-term primary cell-based platform called reformed islets to study mouse and human islet biology, showing they retain key physiological and functional features of native islets.

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

The paper identifies PLEKHS1 as a driver of PI3K activity in PTEN-null prostate tissue, showing it bypasses feedback mechanisms to promote tumour progression.

P-Selectin promotes SARS-CoV-2 interactions with platelets and the endothelium

This study identifies P-selectin as a novel SARS-CoV-2 spike receptor that promotes viral interactions with platelets and endothelium, facilitating viral localization in airway capillaries.

Bivalent mRNA vaccine improves antibody-mediated neutralization of many SARS-CoV-2 Omicron lineage variants

This study evaluates the neutralizing antibody response to bivalent mRNA vaccines against multiple Omicron variants, showing enhanced neutralization against BQ.1 and BQ.1.1.

Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity

The paper shows that mouse and human kidneys produce biologically active vasopressin in response to NaCl-induced hypertonicity and water restriction.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

In vivo modelling of patient genetic heterogeneity identifies concurrent Wnt and PI3K activity as a potent driver of invasive cholangiocarcinoma growth.

This study identifies concurrent Wnt and PI3K activity as drivers of invasive cholangiocarcinoma growth and shows that their co-inhibition slows tumor growth in vivo.

High Light and High Temperature Reduce Photosynthesis via Different Mechanisms in the C4 Model Setaria viridis

This study examines how high light and high temperature affect photosynthesis in Setaria viridis, revealing distinct mechanisms and acclimation strategies in C4 plants.

SARS-CoV-2 susceptibility of cell lines and substrates commonly used in diagnosis and isolation of influenza and other viruses

This study evaluates SARS-CoV-2 susceptibility in cell lines used for influenza and other virus diagnosis, finding that some are permissive while others are not, with MDCK cells being insusceptible due to low ACE2 expression.

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

Evaluating geographic variation within molecular operational taxonomic units (OTUs) using network analyses in Scandinavian lakes

The paper evaluates geographic variation within molecular operational taxonomic units using network analyses on metabarcoding data from Scandinavian lakes and finds no assortative clustering or increased connectivity between neighboring lakes.

Wnt-and Glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division

This study shows that Wnt and glutamate receptors coordinate stem cell dynamics and asymmetric division through receptor-mediated signaling and spindle orientation.

Adaptive Baseline Fitting for 1H MR Spectroscopy Analysis

This paper introduces ABfit, an adaptive baseline fitting algorithm for 1H MR spectroscopy that optimizes smoothness penalties using the Akaike information criterion, improving metabolite estimation accuracy.

Determinants of anemia among pregnant women in northern Ghana

This study investigates determinants of anemia in pregnant women in northern Ghana, finding that deworming medication reduces moderate/severe anemia risk, while occupation and parity increase it.

Genetic and physical interactions between the organellar mechanosensitive ion channel homologs MSL1, MSL2, and MSL3 reveal a role for inter-organellar communication in plant development

This study shows that MSL1, MSL2, and MSL3 interact genetically and physically, suggesting inter-organellar communication is important for plant development.

Subtractive Interaction Proteomics Reveal a Network of Signaling Pathways Activated by an Oncogenic Transcription Factor in Acute Myeloid Leukemia

This study uses subtractive interaction proteomics to identify signaling pathways activated by the t(6;9)-DEK/CAN oncogene in AML, revealing potential therapeutic targets.

Social integration predicts mitochondrial DNA copy number in rhesus macaques

The paper examines the relationship between social integration and mitochondrial DNA copy number in rhesus macaques, finding that affiliative social behavior, not dominance rank, is linked to mtDNA copy number in immune cells.