D. Barrick

Unravelling Paralog-Specific Notch Signaling through Ternary Complex Stability and Transcriptional Activation Measurements Using Chimeric Receptors

The paper measures ternary complex stability and transcriptional activation of Notch paralogues and chimeric receptors to understand paralog-specific signaling differences.

The importance of input sequence set to consensus-derived proteins and their relationship to reconstructed ancestral proteins

The paper compares consensus and ancestral protein reconstruction methods using Ribonuclease H sequences, finding that phylogenetically restricted consensus proteins are more stable than those from diverse clades.

Surface residues and non-additive interactions stabilize a consensus homeodomain protein

The paper investigates how substitutions in a consensus homeodomain protein contribute to its stabilization, finding that surface residues and charge-conserving substitutions play key roles.

A collection of programs for one-dimensional Ising analysis of linear repeat proteins with point substitutions

The paper presents programs for analyzing the thermodynamics of linear repeat proteins using a 1D Ising model to study folding and mutation effects.

Consensus sequence design as a general strategy to create hyperstable, biologically active proteins

This study evaluates consensus sequence design for creating stable, biologically active proteins across six families, finding high success rates in stability and function.

Functional instability allows access to DNA in longer Transcription Activator-Like Effector (TALE) arrays.

The paper examines DNA binding kinetics of TALE arrays using single molecule microscopy and deterministic modeling, revealing functional instability due to conformational heterogeneity.