Author

K. Geiger-Schuller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

D. Barrick· 2 shared A. J. Aguirre· 1 shared A. Jones· 1 shared A. Regev· 1 shared A. Tsherniak· 1 shared A. Warren· 1 shared B. M. Wolpin· 1 shared B. R. Paolella· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiophysics

D. Barrick

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3 papers

Recent·Most cited

A collection of programs for one-dimensional Ising analysis of linear repeat proteins with point substitutions

J. Marold, K. Sforza, K. Geiger-Schuller, T. Aksel, S. Klein, M. Petersen, E. Poliakova-Georgantas, D. Barrick

The paper presents programs for analyzing the thermodynamics of linear repeat proteins using a 1D Ising model to study folding and mutation effects.

bioRxiv · Jun 27, 2020Biophysics

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

J. M. McFarland, B. R. Paolella, A. Warren, K. Geiger-Schuller, T. Shibue, M. Rothberg, O. Kuksenko, A. Jones, E. Chambers, D. Dionne, S. Bender, B. M. Wolpin, M. Ghandi, I. Tirosh, O. Rozenblatt-Rosen, , A. Tsherniak

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

bioRxiv · Dec 8, 2019Cancer Biology

Functional instability allows access to DNA in longer Transcription Activator-Like Effector (TALE) arrays.

K. Geiger-Schuller, J. Mitra, T. Ha, D. Barrick

The paper examines DNA binding kinetics of TALE arrays using single molecule microscopy and deterministic modeling, revealing functional instability due to conformational heterogeneity.

bioRxiv · Jul 5, 2018Biophysics