J. Mitra

Single molecule studies of the native hair cell mechanosensory transduction complex

This study optimizes single molecule assays to detect and quantify the native hair cell mechanosensory transduction complex at attomole levels.

A comparative study of low-pH tolerance and chitinase activity between toxigenic and non-toxigenic strains of Vibrio cholerae

This study compares low-pH tolerance and chitinase activity between toxigenic and non-toxigenic Vibrio cholerae strains, finding that the non-toxigenic strain exhibits greater growth and chitinase activity under acidic conditions.

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

The repeat region of the circumsporozoite protein is an elastic linear spring with a functional role in Plasmodium sporozoite motility

The study identifies the CSP repeat region as a linear spring critical for sporozoite motility and adhesion site formation in malaria parasites.

Real-time monitoring of cotranscriptional riboswitch folding and switching

The paper develops a novel vectorial folding assay to study cotranscriptional riboswitch folding and shows that riboswitch fate is sequence-encoded and controllable by a directionally moving protein.

Streamlining effects of extra telomeric repeat on telomere folding revealed by fluorescence-force spectroscopy

The paper uses fluorescence-force spectroscopy to study how extra telomeric repeats affect G-quadruplex folding dynamics in human telomeric sequences.

Nanomechanics and co-transcriptional folding of Spinach and Mango

This study examines the nanomechanics and co-transcriptional folding of Spinach and Mango aptamers using single-molecule techniques, revealing distinct unfolding and refolding behaviors and the role of ions in their stability.

Functional instability allows access to DNA in longer Transcription Activator-Like Effector (TALE) arrays.

The paper examines DNA binding kinetics of TALE arrays using single molecule microscopy and deterministic modeling, revealing functional instability due to conformational heterogeneity.