T. Aksel

Design principles for accurate folding of DNA origami

The paper establishes design principles for accurate DNA origami folding using thermodynamic modeling and graph-based routing, validated through experimental analysis.

High-density and scalable protein arrays for single-molecule proteomic studies

This paper develops a scalable method to create dense single-molecule protein arrays using DNA origami and surface functionalization, enabling high-sensitivity proteomic analysis.

DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation

The paper uses DNA origami to pattern synthetic T cell receptors and shows how spatial arrangement affects signaling sensitivity and kinetics.

A collection of programs for one-dimensional Ising analysis of linear repeat proteins with point substitutions

The paper presents programs for analyzing the thermodynamics of linear repeat proteins using a 1D Ising model to study folding and mutation effects.

Molecular goniometers for single-particle cryo-EM of DNA-binding proteins

The paper introduces molecular goniometers using DNA origami to precisely orient DNA-binding proteins for cryo-EM, achieving a 6.5 Å structure of BurrH.

Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy

This paper introduces amino and PEG-amino functionalized graphene oxide grids to improve sample concentration, distribution, and protection for cryo-EM.

Construction of a novel phagemid to produce custom DNA origami scaffolds

The paper constructs a novel phagemid, pScaf, to produce custom DNA origami scaffolds with a smaller fixed region, enabling greater design flexibility.