Author

P. K. Fyfe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Hope· 1 shared A.-P. Petit· 1 shared C. J. MacKenzie· 1 shared C. Kerr· 1 shared D. A. Fletcher· 1 shared D. Bubeck· 1 shared D. Porter· 1 shared D. W. Gray· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Hope

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivDec 1, 2023

Application of an NMR/crystallography fragment screening platform for the assessment and rapid discovery of new HIV-CA binding fragments

S. Lang, D. A. Fletcher, A.-P. Petit…·D. W. Gray

The paper uses NMR and crystallography to identify and assess new HIV-CA binding fragments, leading to the discovery of two compounds with improved binding properties.

DOI 10.1002/cmdc.202400025

experimental assaydrug response / drug discovery

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 18, 2022

Structural insights into the assembly and activation of IL-27 signalling complex

Y. Jin, P. K. Fyfe, S. Gardner…·I. Moraga

This study determines the structure of the IL-27 receptor recognition complex using cryoEM, revealing how IL-27 bridges IL-27R and GP130 to initiate signaling.

DOI 10.1101/2022.02.18.481027

cryo-EMexperimental assay

𝕏 PostBluesky