Cancer BiologybioRxiv
p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression
M. Ghosh, S. Saha, J. Li…·L. A. Martinez
This study shows p53 suppresses tumors by promoting TREX1 degradation, leading to cytosolic DNA accumulation and activation of the cGAS/STING pathway, which induces type I interferons.
DOI 10.1016/j.molcel.2022.12.023