FOXA2 controls the anti-oxidant response in FH-deficient cells
C. Rogerson, M. Sciacovelli, L. A. Maddalena, L. Valcarcel-Jimenez, C. Schmidt, M. Yang, E. Ivanova, J. Kent, A. Mora, D. Cheeseman, J. S. Carroll, G. Kelsey, C. Frezza
This study identifies FOXA2 as a key transcription factor regulating the anti-oxidant response in FH-deficient cells, independent of NRF2, and highlights its role in metabolic rewiring.
bioRxiv · Jul 4, 2022Cancer Biology