C. Rogerson

The pioneer transcription factor ELF2 remodels the nucleosome near transcription start sites

This study reveals how ELF2, a pioneer transcription factor, remodels nucleosomes near transcription start sites by unwrapping DNA and exposing chromatin, facilitating transcription initiation.

FOXA2 controls the anti-oxidant response in FH-deficient cells

This study identifies FOXA2 as a key transcription factor regulating the anti-oxidant response in FH-deficient cells, independent of NRF2, and highlights its role in metabolic rewiring.

HIRA loss transforms FH-deficient cells

This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.

Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to Oesophageal Adenocarcinoma

The paper identifies a cell cycle gene expression signature in Oesophageal Adenocarcinoma (OAC) and shows KLF5's repurposing to regulate cell cycle genes during progression from Barrett's oesophagus to OAC.

Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation

This study identifies Akt1-dependent actomyosin remodeling as essential for nuclear lamina dispersal and nuclear shrinkage during keratinocyte terminal differentiation.

Identification of a primitive intestinal transcription factor network shared between oesophageal adenocarcinoma and its pre-cancerous precursor state

This study identifies a primitive intestinal transcription factor network, centered on HNF4A and GATA6, that is active in oesophageal adenocarcinoma and its precursor state, Barretts oesophagus.

Rap1, AF6 and Pak4 cooperate with Par3 to promote ZA assembly and remodeling in the fly photoreceptor

The paper identifies a cooperative role of Rap1, AF6/Cno, and Pak4/Mbt in ZA assembly and remodeling during fly photoreceptor development.