Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
A. C. deCarvalho, H. Kim, L. M. Poisson, M. E. Winn, C. Mueller, D. Cherba, J. Koeman, S. Seth, A. Protopopov, M. Felicella, S. Zheng, A. Multani, Y. Zhang, J. Zhang, D.-H. Nam, , R. Verhaak
This study shows that extrachromosomal DNA elements and chromosomal alterations in glioblastoma have distinct inheritance patterns and contribute to genomic heterogeneity during tumor evolution.
bioRxiv · Jun 27, 2017Cancer Biology