Author

S. Seth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Carugo· 2 shared A. Viale· 2 shared G. Genovese· 2 shared A. C. deCarvalho· 1 shared A. Deem· 1 shared A. Hefner· 1 shared A. K. Deem· 1 shared A. Khalil· 1 shared

Activity by Year

2017-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

A. Carugo

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Author profile →

5 papers

Recent·Most cited

Medium-chain acyl-CoA dehydrogenase, a gatekeeper of mitochondrial function in glioblastoma multiforme

F. Puca, F. Yu, C. Bertolacci, P. Pettazzoni, A. Carugo, E. Huang-Hobbs, J. Liu, C. Zanca, F. Carbone, E. Del Poggetto, J. Gumin, P. Dasgupta, S. Seth, F. F. Lang, E. Sulman, , G. Draetta

This study identifies MCAD as a critical enzyme for fatty acid metabolism in GBM, showing its essential role in preventing mitochondrial damage and apoptosis.

bioRxiv · Sep 28, 2020 · PreprintCancer Biology

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics

J. L. Rose, S. Srinivasan, W. Yao, S. Seth, M. Peoples, A. Machado, C.-Y. Li, I. L. Ho, J. J. Lee, P. A. Guerrero, E. Kim, M. Syed, J. R. Daniele, A. Deem, M. Kim, , G. F. Draetta

This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.

bioRxiv · Sep 17, 2020 · PreprintCancer Biology

Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function.

M. Kumar, D. Molkentine, J. Molkentine, K. Bridges, T. Xie, L. Yang, A. Hefner, M. Gao, M. J. Frederick, S. Seth, M. Abdelhakiem, B. Beadle, F. M. Johnson, J. Wang, L. Shen, , H. D. Skinner

The paper identifies CREBBP/EP300 as radiosensitization targets in mutant tumors by inhibiting histone acetyltransferase, which represses homologous recombination and increases radiation sensitivity.

bioRxiv · Apr 10, 2020 · PreprintCancer Biology

Genetically Encoded, Multivalent Liquid Glycan Array (LiGA)

M. Sojitra, S. Sarkar, J. Maghera, E. Rodrigues, E. J. Carpenter, S. Seth, D. F. Vinals, N. J. Bennett, R. Reddy, A. Khalil, X. Xue, M. Bell, R. B. Zheng, P. Zhang, C. Nycholat, , R. Derda

The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.

bioRxiv · Mar 24, 2020Biochemistry

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

A. C. deCarvalho, H. Kim, L. M. Poisson, M. E. Winn, C. Mueller, D. Cherba, J. Koeman, S. Seth, A. Protopopov, M. Felicella, S. Zheng, A. Multani, Y. Zhang, J. Zhang, D.-H. Nam, , R. Verhaak

This study shows that extrachromosomal DNA elements and chromosomal alterations in glioblastoma have distinct inheritance patterns and contribute to genomic heterogeneity during tumor evolution.

bioRxiv · Jun 27, 2017Cancer Biology