Author

D. Chitayat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

C. S. Asensio· 2 shared J. Klumperman· 2 shared R. E. N. van der Welle· 2 shared T. Veenendaal· 2 shared A. Fasano· 1 shared A. M. Lozano· 1 shared A. Murison· 1 shared A. Rodriguez· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

C. S. Asensio

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mapping the Cellular Origin and Early Evolution of Leukemia in Down Syndrome

E. Wagenblast, J. Araujo, O. I. Gan, S. K. Cutting, A. Murison, G. Krivdova, M. Azkanaz, J. L. McLeod, S. A. Smith, S. A. Marhon, M. Gabra, M. Chan-Seng-Yue, L. Garcia-Prat, L. Salmena, D. D. D. De Carvalho, , E. R. Lechman

This study identifies the cellular origin and mechanisms of leukemia predisposition in Down syndrome by analyzing gene mutations and their effects in fetal hematopoietic cells.

bioRxiv · Nov 29, 2020Cancer Biology

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion

C. H. Burns, B. Yau, A. Rodriguez, J. D. Triplett, D. Maslar, Y. S. An, R. E. N. van der Welle, R. G. Kossina, M. R. Fisher, G. W. Strout, P. O. Bayguinov, T. Veenendaal, D. Chitayat, J. A. J. Fitzpatrick, J. Klumperman, , C. S. Asensio

This study shows that VPS41 deletion in pancreatic beta-cells causes diabetes by impairing insulin secretory granule formation and secretion.

bioRxiv · Apr 25, 2020Physiology

VPS41 recessive mutation causes ataxia and dystonia with retinal dystrophy and mental retardation by inhibiting HOPS function and mTORC1 signaling

R. E. N. van der Welle, R. Jobling, C. Burns, P. Sanza, C. ten Brink, A. Fasano, L. Chen, F. J. Zwartkruis, S. Zwakenberg, E. F. Griffin, J. van der Beek, T. Veenendaal, N. Liv, S. Blaser, C. Sepulveda, , J. Klumperman

This paper identifies VPS41 mutations causing neurodegenerative disease by disrupting HOPS function and mTORC1 signaling, leading to lysosomal dysfunction and impaired autophagy.

bioRxiv · Dec 18, 2019 · PreprintCell Biology