Author

J. A. J. Fitzpatrick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Immunology· 1 Microbiology· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:cryo-EM· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Organism:Arabidopsis· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. J. Rau· 2 shared M. R. Fisher· 2 shared P. O. Bayguinov· 2 shared A. Bredemeyer· 1 shared A. K. Bhadra· 1 shared A. Kovacs· 1 shared A. Rodriguez· 1 shared A. Tripathi· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

M. J. Rau

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Poly-basic peptides and polymers as new drug candidate against Plasmodium falciparum

R. Sivakumar, K. Floyd, E. Jessey, J. Kim Kim, P. Bayguinov, J. A. J. Fitzpatrick, D. Goldfarb, M. Jovanovic, A. Tripathi, S. Djuranovic, S. Pavlovic Djuranovic

This study shows poly-lysine peptides and their modifications can reduce Plasmodium falciparum in human erythrocytes in vitro, with potential as new antimalarial drugs.

bioRxiv · Sep 16, 2023 · PreprintMicrobiology

Lipid nanodisc scaffold and size alters the structure of a pentameric ligand-gated ion channel

V. Dalal, M. J. Arcario, J. T. Petroff, N. M. Dietzen, M. J. Rau, J. A. J. Fitzpatrick, G. Brannigan, W. W. L. Cheng

This study shows that different lipid nanodisc scaffolds and sizes alter the structure of the pentameric ligand-gated ion channel ELIC, with larger nanodiscs promoting more activated conformations.

bioRxiv · Nov 20, 2022Biophysics

Myopathy mutations in DNAJB6 slow conformer specific substrate processing that is rescued by NEF modulation

A. K. Bhadra, M. J. Rau, J. A. Daw, J. A. J. Fitzpatrick, C. C. Weihl, H. True

This study identifies how LGMDD1 mutations in DNAJB6 disrupt chaperone function and shows that modulating NEF can rescue substrate processing defects.

bioRxiv · Dec 22, 2021 · PreprintBiochemistry

Singlet oxygen leads to structural changes to chloroplasts during degradation in the Arabidopsis thaliana plastid ferrochelatase two mutant

K. E. Fisher, P. Krishnamoorthy, M. S. Joens, J. Chory, J. A. J. Fitzpatrick, J. D. Woodson

The paper investigates chloroplast degradation in Arabidopsis thaliana under singlet oxygen stress, finding structural changes and increased plastoglobule activity in degrading chloroplasts.

bioRxiv · Jul 19, 2021Plant Biology

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

N. R. Wong, J. Mohan, B. Kopecky, S. Guo, L. Du, J. Leid, O. Dmytrenko, H. Luehmann, G. Bajpai, L. Ewald, L. Bell, N. Patel, I. Lokshina, A. Bredemeyer, C. J. Weinheimer, , K. J. Lavine

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

bioRxiv · Jan 28, 2021Immunology

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion

C. H. Burns, B. Yau, A. Rodriguez, J. D. Triplett, D. Maslar, Y. S. An, R. E. N. van der Welle, R. G. Kossina, M. R. Fisher, G. W. Strout, P. O. Bayguinov, T. Veenendaal, D. Chitayat, J. A. J. Fitzpatrick, J. Klumperman, , C. S. Asensio

This study shows that VPS41 deletion in pancreatic beta-cells causes diabetes by impairing insulin secretory granule formation and secretion.

bioRxiv · Apr 25, 2020Physiology

Cryo-EM structures of the ATP release channel pannexin 1

Z. Deng, Z. He, G. Maksaev, R. M. Bitter, M. Rau, J. A. J. Fitzpatrick, P. Yuan

This study presents cryo-EM structures of pannexin 1 from Xenopus tropicalis and Homo sapiens, revealing its heptameric architecture and molecular sieve mechanism for ATP release.

bioRxiv · Jan 5, 2020Biophysics