Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer
J. E. Anstee, J. W. Opzoomer, I. Dean, H. P. Muller, M. Bahri, K. Liakath-Ali, Z. Liu, D. Choy, J. Caron, D. Sosnowska, R. Beatson, T. Muliaditan, Z. An, C. E. Gillett, G. Lan, , J. N. Arnold
This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.
bioRxiv · Feb 3, 2022Cancer Biology