Z. An

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

This study compares the genomes of nematode-trapping fungi and non-NTF to identify genomic changes linked to carnivorism and adaptation to post-Permian-Triassic extinction environments.

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV

This paper introduces an ACE2 decamer viral trap that neutralizes multiple SARS-CoV-2 variants and related coronaviruses through inhalation, showing durability and effectiveness in preclinical models.

Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody Responses

This study evaluates multivalent HCMV gB mRNA vaccines in rabbits, finding increased T cell responses but no improvement in antibody breadth.

Discovery of a novel monoclonal PD-L1 antibody H1A that promotes T-cell mediated tumor killing activity in renal cell carcinoma

This study identifies a novel monoclonal PD-L1 antibody H1A that enhances T-cell mediated tumor killing in renal cell carcinoma compared to existing PD-1/PD-L1 inhibitors.

Potent and pan-neutralization of SARS-CoV-2 variants of concern by DARPins

This paper reports the development of two DARPins, FSR16m and FSR22, that potently neutralize SARS-CoV-2 variants, including emerging ones, with efficacy comparable to therapeutic antibodies.

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.

Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors

This study shows that homogeneous antibody-drug conjugates (ADCs) improve therapeutic efficacy in glioblastoma models compared to heterogeneous ADCs.

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

This study identifies the P681R mutation in the Delta variant's spike protein as critical for enhanced viral replication compared to the Alpha variant through increased furin cleavage of the spike protein.

CODEC enables 'single duplex' sequencing

CODEC improves mutation detection by combining NGS throughput with single-molecule resolution, achieving similar accuracy with fewer reads.

Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

Structural basis for HCMV Pentamer recognition by antibodies and neuropilin 2

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

The N501Y spike substitution enhances SARS-CoV-2 transmission

The paper shows the N501Y spike mutation in SARS-CoV-2 enhances viral transmission in hamsters and human airway cells by increasing receptor binding affinity.

Stability of amino acids and related amines in human serum under different preprocessing and pre-storage conditions based on iTRAQ(R)-LC-MS/MS

The paper assesses amino acid and amine stability in human serum under various preprocessing and storage conditions using iTRAQ(R)-LC-MS/MS.

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

This study develops dual-payload antibody-drug conjugates to overcome breast tumor heterogeneity and drug resistance, showing improved efficacy in a xenograft model.

Asprosin Neutralizing Antibodies as a Treatment for Metabolic Syndrome

This paper shows anti-asprosin monoclonal antibodies reduce appetite, body weight, and blood glucose in metabolic syndrome mouse models.

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

This study shows the D614G mutation in SARS-CoV-2 increases viral replication and upper respiratory tract viral loads but does not reduce vaccine efficacy or antibody neutralization.

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

This study characterizes non-neutralizing gB-specific monoclonal antibodies from HCMV-infected individuals, revealing their binding specificity, genotype preference, and effector functions like ADCP and ADCC.

Effects of CEPA and 1-MCP on flower bud differentiation of apple cv. ‘Nagafu No.2’ grafted on different rootstocks

This study examines the effects of CEPA and 1-MCP on flower bud differentiation in apple trees grafted on different rootstocks, finding CEPA promotes flowering while 1-MCP has no significant effect.