Author

R. Beatson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. Grundland Freile· 2 shared J. M. Burchell· 2 shared J. Taylor-Papadimitriou· 2 shared R. Graham· 2 shared T. Ng· 2 shared Z. An· 2 shared Z. Liu· 2 shared A. Skinner· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

F. Grundland Freile

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Author profile →

5 papers

Recent·Most cited

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

J. Deng, T. Pan, Y. Hong, Z. Liu, X. Zhou, Z. An, L. Li, G. Alfano, G. Li, L. Dolcetti, R. Evans, J. M. Vicencio, P. Vlckova, Y. Chen, J. Monypenny, , T. Ng

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

bioRxiv · Aug 10, 2023 · PreprintCancer Biology

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

J. E. Anstee, J. W. Opzoomer, I. Dean, H. P. Muller, M. Bahri, K. Liakath-Ali, Z. Liu, D. Choy, J. Caron, D. Sosnowska, R. Beatson, T. Muliaditan, Z. An, C. E. Gillett, G. Lan, , J. N. Arnold

This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.

bioRxiv · Feb 3, 2022Cancer Biology

Identification of Chlorophyll a-b Binding Protein AB96 as a novel TGFbeta1 binding agent.

S. Lynham, F. Grundland Freile, N. M. Puri, N. O'Reilly, G. H. Mitchell, T. Wells, M. Willcox, R. Beatson

The paper identifies chlorophyll a-b binding protein AB96 as a plant-derived protein that binds to active TGFbeta1, suggesting potential therapeutic applications.

bioRxiv · Aug 20, 2020Immunology

Cancer-associated hypersialylated MUC1 drives the differentiation of monocytes into macrophages with a pathogenic phenotype

R. Beatson, R. Graham, F. Grundland Freile, D. Cozzetto, S. Kannambath, E. Pfeifer, N. Woodman, J. Owen, R. Nuamah, U. Mandel, S. Pinder, C. Gillett, T. Noll, I. Bouybayoune, J. Taylor-Papadimitriou, J. M. Burchell

This study identifies MUC1-ST as a driver of monocyte differentiation into pathogenic macrophages in the tumor microenvironment, associated with poor breast cancer prognosis.

bioRxiv · May 6, 2020Cancer Biology

O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR in breast cancer

V. Tajadura-Ortega, G. Gambardella, A. Skinner, K. Ter-Borch Gram Schjoldager, R. Beatson, R. Graham, D. Achkova, J. Taylor-Papadimitriou, F. D. Ciccarelli, J. Burchell

The paper shows that O-linked glycosylation differences in breast cancer cells lead to distinct gene expression signatures via differential EGFR nuclear translocation.

bioRxiv · Jul 25, 2019Cancer Biology