Author

G. Lan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. DeGiovanni· 1 shared A. E. Taylor· 1 shared A. Jaulim· 1 shared A. Li· 1 shared A. R. J. Young· 1 shared A. S. L. Chan· 1 shared A. Y. Warren· 1 shared C. A. Barcelos· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBioengineering

A. DeGiovanni

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Autophagy maintains the homeostatic environment in the male reproductive accessory organs playing a key role in fertility

A. Jaulim, L. D. Cassidy, A. R. J. Young, A. S. L. Chan, A. Y. Warren, A. E. Taylor, W. Arlt, G. Lan, M. L. Blayney, O. Davidson, C. L. R. Barratt, S. Pacey, M. Narita

This study shows that autophagy is essential for maintaining the function of male reproductive accessory organs, and its inhibition leads to subfertility, with recovery upon autophagy restoration.

bioRxiv · Jul 21, 2023 · PreprintCell Biology

Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A

Y. Peng, Y. Zhang, R. Fang, H. Jiang, G. Lan, Z. Xu, Y. Liu, Z. Nie, L. Ren, F. Wang, S.-D. Zhang, Y. Ma, P. Yang, H.-H. Ge, W.-D. Zhang, , W. He

The paper identifies microtubule-targeting agents that induce CENP-A accumulation by destabilizing Cdh1, linking microtubule dynamics to CENP-A proteolysis.

bioRxiv · Apr 25, 2023Cell Biology

A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Z. Wang, S. Cheong, J. H. Pereira, J. Kim, A. DeGiovanni, Y. Guo, G. Lan, C. A. Barcelos, R. Haushalter, T. S. Lee, P. D. Adams, J. D. Keasling

The paper identifies a Burkholderia polyketoacyl-CoA thiolase with significantly higher TAL production activity than 2-PS, achieving 2.8 g/L in E. coli fermentations.

bioRxiv · Dec 4, 2022 · PreprintBioengineering

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

J. E. Anstee, J. W. Opzoomer, I. Dean, H. P. Muller, M. Bahri, K. Liakath-Ali, Z. Liu, D. Choy, J. Caron, D. Sosnowska, R. Beatson, T. Muliaditan, Z. An, C. E. Gillett, G. Lan, , J. N. Arnold

This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.

bioRxiv · Feb 3, 2022Cancer Biology