The BRD4S-LOXL2-MED1 interaction at the forefront of cell cycle transcriptional control in triple-negative breast cancer
L. Pascual-Reguant, T. V. Tian, D. Datta, D. Cianferoni, S. Kourtis, A. Ganez Zapater, C. Cannata, Q. Serra Camprubi, L. Espinar, M. Guirola, J. Querol, A. Miro Canturri, J. Arribas, L. Serrano, S. Peiro, S. Sdelci
This study shows that inhibiting LOXL2 and BRD4 together reduces triple-negative breast cancer proliferation by disrupting the BRD4S-LOXL2-MED1 interaction that controls cell cycle gene expression.
bioRxiv · May 27, 2022 · PreprintCancer Biology