Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19
S. A. Apostolidis, A. Sarkar, H. M. Giannini, R. R. Goel, D. Mathew, A. Suzuki, A. E. Baxter, A. R. Greenplate, C. Alanio, M. Abdel-Hakeem, D. A. Oldridge, J. R. Giles, J. E. Wu, Z. Chen, Y. J. Huang, , E. J. Wherry
This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.
Frontiers in Immunology · Mar 3, 2022Peer-reviewedImmunology