V. Herder

A Machine Learning Framework to Identify the Correlates of Disease Severity in Acute Arbovirus Infection

This study uses machine learning to identify key viral and host processes associated with varying severity in bluetongue virus infection in sheep.

Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response

The paper presents a spatially resolved single-cell atlas of lung tissue from fatal Covid19 cases in an African population, revealing a distinct cellular signature and an interferon gamma-dominated response.

The SARS-CoV-2 Omicron sub-variant BA.2.86 is attenuated in hamsters

The paper assesses the virulence of the SARS-CoV-2 BA.2.86 variant in hamsters and finds it is attenuated compared to BA.2.75.

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning

This study develops quantitative pipelines using digital pathology and machine learning to assess the virulence of SARS-CoV-2 variants in hamsters, showing that some Omicron sub-lineages have regained virulence.

Zoonotic avian influenza viruses evade human BTN3A3 restriction

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of the induction of IFN-mediated innate immune defences

This study shows that elevated temperatures inhibit SARS-CoV-2 replication in respiratory epithelium without triggering IFN-mediated immune responses.

Respiratory disease in cats associated with human-to-cat transmission of SARS-CoV-2 in the UK

This study reports two cases of SARS-CoV-2 infection in UK cats linked to human-to-cat transmission, showing mild to severe respiratory disease and genetic variation in the viral genome.