A. Sarkar

Nuclease-Resistant L-DNA Tension Probes Enable Long-TermForce Mapping of Single Cells and Cell Consortia

This paper introduces L-DNA tension probes that resist nuclease degradation, enabling long-term force mapping of single cells and migrating cell populations.

Multiple clustered centrosomes in antigen-presenting cells foster T cell activation without MTOC polarization

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

Spectrally Resolved Single Molecule Orientation Imaging Reveals Direct Correspondence between Polarity and Order Experienced by Nile Red in Supported Lipid Bilayer Membrane

The paper uses spectrally resolved single molecule orientation imaging to show a direct link between polarity and order in lipid bilayers.

G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics

This study introduces CAPRIs, bispecific antibodies that inhibit platelet activation by clustering G6B with ITAM receptors, showing effectiveness in preventing thrombus formation without causing bleeding.

Confinement in fibrous environments positions and orients mitotic spindles

This study investigates how ECM-confinement affects mitotic spindle positioning and orientation through mechanical interactions and RF patterning.

Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet.

This study shows that inhibiting a non-canonical gp130 signaling pathway reduces chronic inflammation and multimorbidity in a high-fat diet model.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

Design and Assembly of a Cargo-agnostic Hollow Two-lidded DNA Box for Drug Delivery

This paper designs and assembles a hollow two-lidded DNA box for drug delivery, demonstrating stability and cargo loading capabilities.

Video-Microscopy-Based Automated Trajectory Determination for High-Velocity, Densely Clustered, Indistinguishable Objects Moving in A Directed Force Field

The paper introduces an automated trajectory tracking method for high-velocity, densely clustered, indistinguishable objects in a directed force field, demonstrating its effectiveness through simulations and experimental data.

A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Range of Human and Viral CaaX Sequences

The paper develops humanized yeast strains expressing human prenyltransferases to study prenylation of diverse CaaX sequences from human and viral proteins.

Selective refueling of CAR T cells using ADA1 and 1 CD26 boosts antitumor immunity

This study shows that engineering CAR T cells to co-express ADA1 and CD26 improves their antitumor activity by selectively refueling them with inosine in the tumor microenvironment.

A comprehensive analysis of Transcribed Ultra Conserved Regions uncovers important regulatory functions of novel non-coding transcripts in gliomas.

This study analyzes Transcribed Ultra Conserved Regions (TUCRs) in gliomas, identifying uc.110 as a tumor enhancer that promotes malignancy via the WNT pathway.

A benzoxazolylurea inhibits VraS and enhances antimicrobials against vancomycin intermediate-resistant Staphylococcus aureus

Differences in the activities of domain-swapped chimeras of two homologous GH57 glucanotransferases suggest that a glucan-binding DUF could influence donor substrate specificity

The paper shows that domain 3 of GH57 glucanotransferases determines donor substrate specificity through a glucan-binding site at its domain interface.

A glucanotransferase that uses two sub-sites and four catalytic aspartates/glutamates to disproportionate oligosaccharides ranging in length from maltotriose to starch

This paper demonstrates that PfuAmyGT is an exo-amylase-cum-glucanotransferase capable of transferring glucose and disproportionating oligosaccharides using separate sub-sites for donor and acceptor binding.

Analytical code sharing practices in biomedical research

This study analyzes code sharing practices in biomedical research and finds that less than half of manuscripts share analytical code, with significant associations between code availability statements and actual code sharing.

Combined, yet Separate: cocktails of carriers (not drugs) for α-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers

This study demonstrates that using two separate carriers for alpha-particle therapy improves tumor growth inhibition and survival in cancers with low target marker expression, without increasing radioactivity.

Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury

This study shows that stabilizing neutrophil extracellular traps (NETs) with platelet factor 4 reduces thrombogenicity and endothelial cell injury in sepsis.

Prevention of thrombocytopenia and thrombosis in heparin-induced thrombocytopenia (HIT) using deglycosylated KKO: A novel therapeutic?

This paper demonstrates that deglycosylated KKO (DGKKO) can prevent and reverse thrombocytopenia and thrombosis in a HIT murine model.

Allosteric Inhibition of PTP1B by a Nonpolar Terpenoid

This study identifies amorphadiene as a selective allosteric inhibitor of PTP1B, showing it binds to multiple sites on the C-terminus and stabilizes the PTP1B-AD complex.

LDL1 and LDL2 histone demethylases interact with FVE to regulate flowering in Arabidopsis

The paper shows LDL1 and LDL2 histone demethylases interact with FVE to repress floral repressors and regulate flowering in Arabidopsis.

Unlocking the microblogging potential for science and medicine

The paper analyzes Twitter activity of 6,000 biomedical scientists, finding gender differences in tweeting behavior and engagement patterns.

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

The paper identifies antibody responses against non-canonical and endemic coronavirus antigens as predictors of favorable outcomes in severe COVID-19.

Quinacrine binds to the kinase domain of FGFR1 and inhibits its activity

This study shows quinacrine binds to FGFR1's kinase domain, inhibits its activity, and reduces phosphorylation, proliferation, and migration in cancer cells.

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver.

This study shows intermittent fasting induces rapid hepatocyte proliferation in mice to maintain liver-to-body-mass ratio, challenging the view that liver tissue is quiescent unless injured.

Hepatocyte Cell Cycle Progression Depends on a Transcriptional Repressor Cascade Downstream of Wnt Signaling

The paper identifies a transcriptional repressor cascade downstream of Wnt signaling that controls hepatocyte cell cycle progression by repressing E2F7 and E2F8.

gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes

This study shows that gp130/STAT3 signaling is essential for chondrocyte proliferation and anabolism, with loss leading to growth defects and cartilage dysfunction.

A force-balance model for centrosome positioning and spindle elongation during Interphase and Anaphase B

The paper develops a computational model to explain centrosome positioning and spindle elongation during interphase and anaphase B by simulating forces from astral microtubules and interpolar microtubules.

Early loss of endogenous NAD+ following rotenone treatment leads to Sarm1 induction that is ameliorated by PARP inhibition

This study shows that rotenone treatment causes early NAD+ loss, leading to Sarm1 activation, which is prevented by PARP inhibition in both cell cultures and Drosophila.

Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.