The antimicrobial activity of the macrophage metabolite itaconate is synergistic with acidity.
D. Duncan, A. Lupien, M. Behr, K. Auclair
This study shows itaconate's antimicrobial activity synergizes with acidity, suggesting it may function in acidic environments like phagolysosomes and highlights potential therapeutic strategies.
bioRxiv · Aug 5, 2020Microbiology