Author

A. Lupien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. R. Sullivan· 2 shared M. A. Behr· 2 shared M. Behr· 2 shared A. Vocat· 1 shared C. Courtine· 1 shared C. Hamela· 1 shared C. S.-Y. Foo· 1 shared D. Duncan· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

J. R. Sullivan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Discovery of benzophenanthridine derivatives with potent activity against multidrug resistant Mycobacterium tuberculosis

Z. Sun, Y. C. Liang, L. Chen, A. Lupien, Z. Xu, S. Berton, M. Behr, W. Yang, J. Sun

This study identifies two benzophenanthridine derivatives with potent anti-Mtb activity, effective against multidrug-resistant strains and comparable to rifampicin.

bioRxiv · Nov 7, 2022Microbiology

Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

J. R. Sullivan, J. Yao, C. Courtine, A. Lupien, J. Herrmann, R. Müller, M. A. Behr

bioRxiv · Jun 27, 2022Microbiology

Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline

J. R. Sullivan, A. Lupien, E. Kalthoff, C. Hamela, L. Taylor, K. A. Munro, T. M. Schmeing, L. Kremer, M. A. Behr

The paper shows that combining epetraborole with norvaline enhances efficacy against Mycobacterium abscessus in a murine model.

bioRxiv · Jun 1, 2021Microbiology

The antimicrobial activity of the macrophage metabolite itaconate is synergistic with acidity.

D. Duncan, A. Lupien, M. Behr, K. Auclair

This study shows itaconate's antimicrobial activity synergizes with acidity, suggesting it may function in acidic environments like phagolysosomes and highlights potential therapeutic strategies.

bioRxiv · Aug 5, 2020Microbiology

Structure-based drug design and characterization of sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from Mycobacterium tuberculosis

J. Piton, A. Vocat, A. Lupien, C. S.-Y. Foo, O. Riabova, V. Makarov, S. T. Cole

The paper designs and characterizes sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from M. tuberculosis, finding they have improved solubility but lower activity than MCZ.

bioRxiv · Apr 10, 2018Pharmacology & Toxicology