F. Thomas

Aberrant CD4+ T cell refeeding response impairs neuro-immune crosstalk in Parkinson's disease

The paper shows that PD patients have altered CD4+ T cell responses to fasting/refeeding, leading to impaired neuro-immune signaling through a dysfunctional metabolic program in neurons.

Year-round quantification, structure and dynamics of epibacterial communities from diverse macroalgae reveal a persistent core microbiota and strong host specificities

The paper quantifies and analyzes epibacterial communities on macroalgae over a year, revealing a persistent core microbiome and strong host-specific associations.

Universal protection of allogeneic cell therapies from natural killer cells via CD300a agonism

This paper develops CD300a TASR, an engineered ligand that universally protects HLA-deficient allogeneic T cells from NK cell rejection and enhances CAR-T efficacy.

De novo evolution of transmissible tumors in Hydra

This study observes the de novo evolution of transmissible tumors in Hydra through artificial selection and characterizes their biological features and host impacts.

Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

This study shows that blocking CSF-1R in tumor-associated macrophages alters their metabolism, enhancing sensitivity to 5-fluorouracil in colorectal cancer.

Consequences of Cancer on Zebrafish Danio rerio: Insights into Sex Determination, Sex Ratio, and Offspring Survival.

This study investigates whether cancer in zebrafish affects offspring sex ratio and survival, finding no effect on sex ratio but higher offspring survival from cancerous females.

Novel laminarin-binding CBMs in multimodular proteins of marine Bacteroidota feature prominently in phytoplankton blooms

The paper identifies and characterizes novel laminarin-binding CBMs in marine Bacteroidota, showing their prevalence in phytoplankton blooms.

Marine transmissible cancer navigates urbanised waters, threatening to spillover

The paper investigates the spread of a transmissible cancer in mussels, finding higher prevalence in ports and suggesting human activities facilitate its transmission.

Seasonal dynamics of a glycan-degrading flavobacterial genus in a tidally-mixed coastal temperate habitat

The paper investigates seasonal dynamics of the glycan-degrading flavobacterial genus Zobellia in a coastal habitat, showing its abundance and activity vary with environmental factors and seasonal changes.

Zobellia alginoliquefaciens sp. nov. , a new flavobacteria isolated from the epibiota of the brown alga Ericaria zosteroides (C.Agardh) Molinari & Guiry 2020

The paper describes the discovery and characterization of a new flavobacteria species, Zobellia alginoliquefaciens, isolated from the brown alga Ericaria zosteroides.

Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancerous traits and oncogenic pathways shared among bilaterians

The paper performs transcriptomic analysis of MtrBTN2 transmissible cancer cells to identify oncogenic traits and shared pathways among bilaterians.

Metabolic strategies of sharing pioneer bacteria mediating fresh macroalgae breakdown

This study investigates how pioneer bacteria in the genus Zobellia degrade fresh macroalgae, revealing their metabolic strategies and cooperative interactions.

Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

This study identifies hypoxia-driven DPD expression in tumor-associated macrophages as a mechanism of 5-FU chemoresistance in colorectal cancer, with species-specific differences observed between human and mouse models.

Indigenous plants promote insect biodiversity in urban greenspaces

This study shows that indigenous plants, especially graminoids, support higher insect biodiversity in urban greenspaces compared to nonnative species.

Loss of cerebellar function selectively affects intrinsic rhythmicity of eupneic breathing

The paper examines the effect of cerebellar dysfunction on respiratory rhythmicity in mice, finding reduced variability in intrinsic breathing rhythms without changes in average rate or CV.

Infection triggers tumor regression through activation of innate immunity in Drosophila

The study shows bacterial infections reduce tumor size in Drosophila by enhancing innate immune pathways like Imd and Toll.

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

The paper shows PMDs are hypervariable in breast cancer and drive CGI hypermethylation, but do not significantly repress cancer genes.

Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparum

The paper shows that Plasmodium falciparum increases mosquito anthropophagy in infectious females, enhancing parasite transmission.

Can malaria parasites manipulate the odour-mediated host preference of their mosquito vectors?

This study investigates whether malaria parasites manipulate mosquito host choice toward suitable hosts, finding no effect on activation rate or odour preference in infected mosquitoes.